Thiazolidinediones improve -cell function in type 2 diabetic patients
نویسندگان
چکیده
Amalia Gastaldelli, Ele Ferrannini, Yoshinori Miyazaki, Masafumi Matsuda, Andrea Mari, and Ralph A. DeFronzo Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; Metabolism Unit, Department of Internal Medicine, University of Pisa School of Medicine and Institute of Clinical Physiology, National Research Council, Pisa; and CNR Institute of Biomedical Engineering, Padua, Italy
منابع مشابه
Role of thiazolidinediones in the management of type 2 diabetes: focus on ethnic minority populations.
Persons from ethnic minority populations in the United States suffer disproportionately more from type 2 diabetes and its complications than do Caucasians. Genetic and acquired factors likely contribute to the ethnic disparities of type 2 diabetes. The pathophysiologic hallmarks consist of insulin resistance, progressive pancreatic beta-cell dysfunction, and excessive hepatic glucose production...
متن کاملThiazolidinediones improve beta-cell function in type 2 diabetic patients.
Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). There is growing evidence from in vivo and in vitro studies that TZDs improve pancreatic beta-cell function. The aim of this study was to determine whether TZD-induced improvement in glycemic control is associated with improved beta-cell function. We studied 11 normal glu...
متن کاملThiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.
Thiazolidinediones (TZDs) are a new class of insulin-sensitizing drugs. To explore how and in which tissues they improve insulin action, we obtained fat and muscle biopsies from eight patients with type 2 diabetes before and 2 months after treatment with rosiglitazone (n = 5) or troglitazone (n = 3). TZD treatment was associated with a coordinated upregulation in the expression of genes and syn...
متن کاملRosiglitazone decreases albuminuria in type 2 diabetic patients.
Thiazolidinediones are insulin-sensitizing compounds that reduce plasma glucose and improve the lipid profile of type 2 diabetic patients. We determined the effect of rosiglitazone in 15 type 2 diabetic patients and compared these results to 14 randomly assigned placebo patients. After 3 months, the urinary albumin to creatinine ratio was significantly decreased, while the glucose metabolic cle...
متن کاملImpact of Magnesium Deficiency on Pancreatic β-Cell Function in Type 2 Diabetic Nigerians
Objective: Pancreatic b-cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and potentially influenced by several factors. The Magnesium (Mg) deficiency mediates insulin resistance but reports regarding its role in pancreatic β-cell dysfunction are scarce and co...
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تاریخ انتشار 2007